Mary, an out-of-work struggling actress, takes a job as a call-in "Virgin Mary" at the titular hotline. It's a new role, she reasons, to tide herself over until she can return to the stage. Peggy, a health-education teacher at an all-girls Catholic high school, breaks rank with her abstinence curriculum and decides (after seeing one student too many become pregnant) to teach a birth-control lesson. When her lesson is brought to the attention of the school board, she must face the consequences of her decision. Facing parallel quarter-life crises, both Mary and Peggy discover how seemingly temporary choices can have permanent impact, affecting identity, career, love, and spirituality, and that certain decisions can unexpectedly shape a whole life.